Examples:

• Even though they are twins, John and Jake are like chalk and cheese.
• Her personality and mine are like chalk and cheese.
• The new software and the old version are like chalk and cheese.
• Their parenting styles are like chalk and cheese.
• You and your brother are like chalk and cheese.
• The two politicians' views on healthcare are like chalk and cheese.
• My tastes and his are like chalk and cheese.
• The two managers' approaches to leadership are like chalk and cheese.
• Their opinions on the project are like chalk and cheese.
• The two restaurants, although next to each other, are like chalk and cheese.
• Her fashion sense and mine are like chalk and cheese.
• The sisters' personalities are like chalk and cheese.
• Our vacation preferences are like chalk and cheese.
• Their strategies for solving the problem are like chalk and cheese.
• The two artists' styles are like chalk and cheese.
• The new employee and the previous one are like chalk and cheese.
• Their ideas for the business plan were like chalk and cheese.
• The two cities are like chalk and cheese in terms of culture.
• Their methods of teaching are like chalk and cheese.
• The siblings' attitudes towards money are like chalk and cheese.
• The movie and the book are like chalk and cheese.
• Their approaches to dieting are like chalk and cheese.
• The old CEO and the new one are like chalk and cheese.
• His cooking and mine are like chalk and cheese.
• The candidates' speeches were like chalk and cheese.