Examples:

• The adult rat, rabbit or guinea pig may be used.
• Unlike guinea pig tests the LLNA does not require that challenged-induced dermal hypersensitivity reactions be elicited.
• Furthermore, the LLNA does not require the use of an adjuvant, as is the case for the guinea pig maximisation test (13).
• Furthermore, the LLNA does not require the use of an adjuvant, as is the case for the guinea pig maximisation test.
• Furthermore, the LLNA: BrdU-ELISA does not require the use of an adjuvant, as is the case for the guinea pig maximisation test (Chapter B.6 of this Annex, 13).
• Reductions in female guinea pig fertility were observed in one study at doses in excess of the human dose; natalizumab did not affect male fertility.
• Unlike guinea pig tests (i.e. B.6; OECD Test Guideline 406) (13) the LLNA does not require that challenge-induced dermal hypersensitivity reactions be elicited.
• It has, however, the potential to reduce animal use for this purpose when compared to the guinea pig tests (B.6; OECD Test Guideline 406) (14).
• It has, however, the potential to reduce the animal use for this purpose when compared to the guinea pig tests (B.6; OECD Test Guideline 406) (13).
• Chapter B.6 of this Annex and OECD Test Guideline 406 utilise guinea pig tests, notably the guinea pig maximisation test and the Buehler test (13).